Fri Feb 10 2023

154 articles - From Friday Feb 03 2023 to Friday Feb 10 2023

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Am J Gastroenterol

Management of Patients With Acute Lower Gastrointestinal Bleeding: An Updated ACG Guideline.

We recommend that most patients requiring inpatient colonoscopy undergo a nonurgent colonoscopy because performing an urgent colonoscopy within 24 hours of presentation has not been shown to improve important clinical outcomes such as rebleeding. Finally, we provide updated recommendations regarding resumption of antiplatelet and anticoagulant medications after cessation of LGIB.

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Gastroenterology

AGA Clinical Practice Update on Diagnosis and Management of Acute Hepatic Porphyrias: Expert Review.

BEST PRACTICE ADVICE 11: Patients with AHP on treatment should undergo surveillance for chronic kidney disease annually with serum creatinine and estimated glomerular filtration rate. BEST PRACTICE ADVICE 12: Patients should be counseled on the chronic and long-term complications of AHP, including neuropathy, chronic kidney disease, hypertension, and hepatocellular carcinoma, and need for long-term monitoring.

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Hepatology

AASLD practice guidance on the clinical assessment and management of nonalcoholic fatty liver disease.

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Meta-analysis

meta-analyses and systematic reviews

Aliment Pharmacol Ther

Meta-analysis: Real-world effectiveness and safety of ustekinumab in patients with ulcerative colitis.

This meta-analysis confirms the effectiveness and safety of ustekinumab in a highly treatment-refractory population of UC patients.

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Am J Gastroenterol

Patients with Crohn's disease and permanent ileostomy are universally excluded from clinical trials: A systematic review.

There is an urgent need to identify barriers to enrollment and develop eligibility and outcome measures enabling the inclusion of patients with CD and PI into clinical trials.

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Systematic Review and Meta-Analysis on the Effects of Lactulose and Rifaximin on Patient-Reported Outcomes in Hepatic Encephalopathy.

Patients with HE treated with lactulose or rifaximin reported improvements in important PROs. These results may inform provider-patient communication and help manage patient expectations regarding the potential benefits of HE therapies.

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Clin Gastroenterol Hepatol

Efficacy of elimination diets in eosinophilic esophagitis: a systematic review and meta-analysis.

Dietary therapy is an effective treatment for EoE patients of any age. The current results could support a trend towards less restrictive dietary regimens as a primary treatment option.

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Food Processing and Risk of Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.

Higher ultra-processed food and lower unprocessed/minimally processed food intakes are associated with higher risk of CD but not UC.

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Gastrointest Endosc

Performance and safety of motorized spiral enteroscopy: a systematic review and meta-analysis.

Motorized spiral enteroscopy provides high rates of diagnostic and therapeutic success with a low prevalence of severe adverse events.

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Hepatology

Letter to the Editor: More efforts for the meta-analysis of the association between hepatic steatosis and HBV-related HCC.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther

Antioxidants, minerals and vitamins in relation to Crohn's disease and ulcerative colitis: A Mendelian randomization study.

Our study provided evidence that circulating levels of antioxidants, minerals and vitamins might be causally linked to the development of IBD.

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Case-control study of the concurrence of coeliac disease with inflammatory bowel disease.

The previously reported positive association between coeliac disease and IBD may have been possibly biased by the inclusion of MC cases in the IBD patient population.

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Efficacy of 1-kestose supplementation in patients with mild to moderate ulcerative colitis: A randomised, double-blind, placebo-controlled pilot study.

Oral 1-kestose is well tolerated and provides clinical improvement for patients with mild to moderate ulcerative colitis through modulation of the gut microbiome.

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Randomised clinical trial: Psychological intervention improves work productivity and daily activity by reducing abdominal pain and fatigue in Crohn's disease.

COBMINDEX is effective at reducing abdominal pain and fatigue in patients with CD, which in turn leads to improvement in functioning. Clinicians should incorporate screening for severe abdominal pain and fatigue and consider offering cognitive-behavioural and mindfulness training. , Number NCT05085925. Ministry of Health in Israel (

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Randomised clinical trial: Safety, tolerability, pharmacodynamics and pharmacokinetics of zastaprazan (JP-1366), a novel potassium-competitive acid blocker, in healthy subjects.

Zastaprazan was safe and well tolerated after a single oral dose up to 60 mg and multiple oral doses up to 40 mg. It also showed rapid, potent suppression of gastric acid secretion. Pharmacodynamic and pharmacokinetic profile of zastaprazan was suitable for treatment of patients with acid-related diseases.

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Am J Gastroenterol

A Prospective Study of Preemptive Tenofovir Disoproxil Fumarate Therapy in HBsAg-Positive Patients With Diffuse Large B-Cell Lymphoma Receiving Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone.

Preemptive TDF therapy in HBsAg-positive patients with diffuse large B-cell lymphoma receiving R-CHOP chemotherapy was safe and effective for preventing HBV-related hepatitis. However, a long-term maintenance strategy of preemptive TDF therapy should be recommended because of the relatively high rate of HBV-related hepatitis after withdrawal from TDF ( ClinicalTrials.gov ID NCT02354846).

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A Randomized, Double-Blind, Controlled Trial of Percutaneous Tibial Nerve Stimulation With Pelvic Floor Exercises in the Treatment of Childhood Constipation.

PTNS with PFE is a safe and effective method in the treatment of childhood constipation, particularly in children with PFD or dyssynergic defecation.

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COVID-19 Vaccine Effectiveness Against the Omicron Variant in a Veterans Affairs Cohort of Patients With Inflammatory Bowel Disease.

The boosted state was associated with a lower risk of SARS-CoV-2 infections and COVID-19-related hospitalization. Efficacy was lower than what has been seen against previous variants and decreased with prolonged duration from the booster. These findings suggest that patients with IBD, especially those who are immunosuppressed, should consider getting a second booster as per Centers for Disease Control and Prevention recommendations.

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Early Antibody Dynamics in a Prospective Cohort of Children At Risk of Celiac Disease.

Anti-DGPs IgG can represent an early preclinical biomarker predicting CD onset in children at risk.

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Epidemiology and Economic Burden of Acute Infectious Gastroenteritis Among Adults Treated in Outpatient Settings in US Health Systems.

AGE is a common and costly disease affecting adults of al ages and more females than males, including individuals with or without baseline conditions in a hospital-based outpatient setting. C. difficile was the most common pathogen detected.

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Evaluating a Novel, Portable, Self-Administrable Device ("Beacon") that Measures Critical Flicker Frequency as a Test for Hepatic Encephalopathy.

Beacon can be self-administered by patients with chronic liver disease and cirrhosis to measure CFF, a validated screening test for minimal hepatic encephalopathy.

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Factors Associated With Placebo Treatment Response in Functional Dyspepsia Clinical Trials.

The findings of this study yield actionable insights into trial methodology that may help to reduce the magnitude of the placebo effect in future functional dyspepsia treatment trials.

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Has the Incidence of Inflammatory Bowel Disease Peaked? Evidence From the Population-Based NorDIBD Cohort 1978-2020.

Our population-based NorDIBD cohort suggests stabilizing of the incidence of IBD in Denmark, whereas the prevalence continues to rise. Because the data represent a 10% sample of the entire Danish IBD population, we believe that data can be extrapolated to the IBD population in general and used for healthcare planning.

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Incidence of cirrhosis among recent immigrants and refugees to Ontario, Canada.

N=25,054 immigrants/refugees were identified with rates of cirrhosis lower compared to Canadian/long-term residents for al etiologies expect HBV likely explained by the health immigrant effect. NAFLD was the most common etiology of cirrhosis among immigrants and refugees.

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Liver Cirrhosis Increases the Risk of Herpes Zoster: A Nationwide Population-based Cohort Study.

Patients with LC, particularly those who are not currently recommended for HZ vaccination, were at an increased risk of HZ and HZ-related hospitalization compared to the general Korean population.

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Ten-Day Vonoprazan-Amoxicillin Dual Therapy as a First-Line Treatment of Helicobacter pylori Infection Compared With Bismuth-Containing Quadruple Therapy.

pylori infection. However, the efficacy of VA-dual therapy was not acceptable.

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Withdrawal of long-term nucleotide analogue therapy in chronic hepatitis B: Outcomes from the withdrawal phase of the HBRN immune active treatment trial.

Results from this trial do not support TDF withdrawal as a therapeutic strategy. HBsAg loss was infrequent within 2 years of stopping long-term TDF. If withdrawal is considered, HBV DNA should be carefully monitored with reinitiation of therapy if levels rise above 4 log10IU/mL to reduce the risk of ALT flares, as they were not associated with subsequent HBsAg decline or loss.

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Working to Answer the Effectiveness of Nutrition in IBD: Still a Ways to Go.

These dietary studies are a welcome addition to a poorly understood field of dietary management of IBD, we explore some practical challenges including trial designs, recruitment, and retention in long term dietary intervention studies. Future dietary intervention studies should, therefore, incorporate endoscopic end points to establish a true anti-inflammatory response to elimination diets, preferably with detailed multi-omics analysis to understand mechanism of action.

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Clin Gastroenterol Hepatol

Adalimumab in biologic-naïve patients with Crohn's disease after resolution of an intra-abdominal abscess: a prospective study from the GETAID.

Provided that the abscess was carefully managed before initiating medical treatment, this study showed the high efficacy of ADA in the short and long term in biologic-naïve patients with CD complicated by an intra-abdominal abscess.

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Diagnostic value of adding magnifying chromoendoscopy to magnifying narrow-band imaging endoscopy for colorectal polyps.

In this multicenter prospective study, we demonstrated the additional value of MCE on M-NBI and suggested that additional MCE be recommended for lesions with low confidence or the ones diagnosed as =T1b CRC.

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Saroglitazar, A Dual PPAR a/ Agonist, Improves Atherogenic Dyslipidemia in Patients with Non-Cirrhotic Nonalcoholic Fatty Liver Disease: A Pooled Analysis.

Saroglitazar improved the serum atherogenic lipoprotein profile in patients with NAFLD, irrespective of co-morbid conditions and statin use. Saroglitazar has the potential to not only positively affect liver disease but also reduce cardiovascular risk in patients with NAFLD.

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The socioeconomic impact of irritable bowel syndrome: an analysis of direct and indirect healthcare costs.

Productivity loss is the main contributor to the socioeconomic burden of IBS. Direct costs were not predominantly related to gastrointestinal care, but rather to mental healthcare. Awareness of the nature of costs and contributing patient factors should lead to significant socioeconomic benefits for society.

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Endosc Int Open

Comparing size measurement of colorectal polyps using a novel virtual scale endoscope, endoscopic ruler or forceps: A preclinical randomized trial.

VSE had significantly higher relative accuracy in measuring polyps compared to ER or BF assisted measurement. VSE improves correct classification of polyps at clinically important size thresholds.

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Endoscopic diagnosis of Helicobacter pylori gastritis using white light imaging and texture and color enhancement imaging.

infection.

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Endoscopic ultrasound in patients with resectable perihilar cholangiocarcinoma: impact on clinical decision-making.

EUS-TA may be of value in patients with potentially resectable pCCA based on preoperative cross-sectional imaging, regardless of lymphadenopathy at cross-sectional imaging. A prospective study in which a comprehensive EUS investigation with LN assessment and EUS-TA of LNs is performed routinely should confirm this promise.

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ERCP for bile duct stones across a national service, demonstrating a high requirement for repeat procedures.

This may have a negative impact on both patient outcomes and experience, and increase pressure on endoscopy services. Apparent variation of outcome between acute hospital care providers requires further analysis.

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Mechanisms of esophageal stricture after extensive endoscopic resection: a transcriptomic analysis.

Our data suggest that IL-1 inhibition or INF supplementation could constitute promising targets for post-endoscopic esophageal stricture prevention.

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Safety and efficacy of a new cold snare technique with clipping for colorectal angioectasia.

CSA was safe and can be a new treatment option in the future. To confirm our results and verify the long-term safety and efficacy of CSA, further studies are desirable.

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Endoscopy

Deep-learning-based clinical decision support system for gastric neoplasms in real-time endoscopy: Development and validation study.

The CDSS demonstrated potential for real-clinic application and high performance in terms of lesion detection and classification of detected lesions in the stomach.

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Effectiveness and safety of cold snare polypectomy and cold endoscopic mucosal resection for 10-19 mm non-pedunculated colorectal polyps: a multicenter observational cohort study.

CSP/C-EMR for morphologically suitable 10-19mm non-pedunculated colonic polyps is effective and safe, including for conventional adenomas. Rates of incomplete resection and recurrence were low, with few adverse events. Studies directly comparing to hot snare resection are required.

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Endoscopic Papillectomy for Ampullary Lesions in patients with Familial Adenomatous Polyposis compared to sporadic lesions in a propensity-score matched cohort.

EP is safe and effective in FAP-related ampullary lesions Criteria for endoscopic resection of AL can be extended to FAP-patients. FAP-patients have a life-time risk to relapse even after complete resection and require long-time-surveillance.

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No-touch endoscopic full-thickness resection technique for gastric gastrointestinal stromal tumors.

CONCLUSIONS : NT-EFTR was a feasible method for the resection of gastric GISTs and can be expected to achieve complete radical resection. Large tumors with extraluminal growth and large gastric defects impact procedural difficulty.

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Prolonged patency of fully covered self-expandable metal stents with an externally anchored plastic stent in distal malignant biliary obstruction.

There were no significant differences in the rates of stent occlusion and adverse events between the two groups. CONCLUSIONS : A novel and simple technique of anchoring an external plastic stent may decrease the risk of FCSEMS migration and prolong stent patency, without significantly increasing the adverse events rate in dMBO.

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Gastroenterology

An Evaluation of Critical Factors for the Cost-Effectiveness of Real-Time CAD: Sensitivity and Threshold Analyses Using a Microsimulation Model.

As CAD is implemented clinically, it needs to improve mean ADR from 26% to at least 30% or cost less than $579 per-colonoscopy to be cost-effective when compared to traditional colonoscopy. Further studies are needed to understand CAD impact in community practice.

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Global epidemiology and genetics of hepatocellular carcinoma.

While there are genetic conditions that confer increased risk for HCC, these diagnoses are rarely recognized outside North America and Europe. In this review, we will evaluate the epidemiological trends and risk factors of HCC, and discuss the genetics of HCC including monogenic diseases, single-nucleotide polymorphisms, gut microbiome, and somatic mutations.

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Hereditary Diffuse Gastric Cancer.

We review the pathology of the disease, the mechanism of tumor initiation and its natural history. Finally, we describe current best practice for the clinical management of HDGC including emerging genetic testing criteria for the identification of new families, methods for endoscopic surveillance, the complications associated with prophylactic surgery, post-operative quality of life and the emerging field of HDGC chemoprevention.

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Low Hepatitis B Core-Related Antigen Levels Correlate Higher Spontaneous Seroclearance of HBsAg in Chronic Hepatitis B Patients with High HBsAg Levels.

Results There were 465 patients who cleared HBsAg with 32414.72 person-years of follow-up with a mean clearance rate of 1.43% per year. We found that lower HBcrAg levels at baseline were associated with an increased likelihood of HBsAg seroclearance (logrank P 1000 IU/mL, clearing HBcrAg may serve as an early biomarker for HBsAg seroclearance.

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PNPLA3 genotype and diabetes identify patients with non-alcoholic fatty liver disease at high risk of incident cirrhosis.

PNPLA3-rs738409 genotype and diabetes identified patients with NAFLD currently considered indeterminate risk (FIB4 1.3-2.67) who had similar risk of cirrhosis as those considered high-risk (FIB4 2.67). PNPLA3 genotyping may improve prognostication and allow for prioritization of intensive intervention.

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Proteome-wide Mendelian randomization identifies causal links between blood proteins and acute pancreatitis.

This large GWAS meta-analysis for AP identified new variants linked with AP as well as several blood proteins that may be causally associated with AP. This study provides new information on the genetic architecture of this disease and identified pathways related to AP, which may be further explored as possible therapeutic targets for AP.

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SOX9 modulates the transformation of gastric stem cells through biased symmetric cell division.

SOX9 marks gastric stem cells and modulates biased symmetric cell division, which appears to be required for the malignant transformation of gastric stem cells.

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Surveillance in Barrett's Esophagus: Challenges, Progress and Possibilities.

Development and implementation of validated quality indicators will allow additional advancement of this critical field. These approaches will hopefully enable efficient and effective cancer prevention and treatment.

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Gastrointest Endosc

A Comparison between Traumatic and Atraumatic Over-The-Scope-Clips in patients with Duodenal Ulcer Bleeding: a Retrospective Analysis with Propensity-Score-based Matching.

OTSC-a should be the preferred option for duodenal ulcer bleeding if the endoscopist aims for an over-the-scope-clip.

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Automated Electronic Health Record-Based Application for Sedation Triage in Routine Colonoscopy.

The EHR-based application, which automates and standardizes determination of sedation type, is a highly beneficial tool that eliminates subjectivity in decision-making, thus allowing for appropriate use of MAC. Complication rates and sedation failure did not increase with use of the application. With the increase in use of MS over MAC, health care costs for the more expensive MAC sedation should also decrease.

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Comparing clinical success and procedural difficulty between treatment-naïve and treatment-refractory patients with esophageal motility disorders during per oral endoscopic myotomy.

Prior treatment did not impact POEM clinical success rate and led to decreased case times and easier tunneling difficulty, likely due to persistent LES changes and differences in diagnostic indications. POEM should be considered for patients with treatment-refractory symptoms as a safe and feasible option. Further large scale studies are needed to validate our findings.

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Computer-Aided Diagnosis of Early-Stage Colorectal Cancer Using Non-Magnified Endoscopic White Light Images.

CADx developed with endoscopic white light images showed excellent per lesion specificity and accuracy for T1b lesion diagnosis, equivalent to experts and superior to trainees. (UMIN000037053) (249 =<250 words).

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Economic impact of implementing optical diagnosis with a "resect and discard" strategy within the English Bowel Cancer Screening Programme: Findings from the DISCARD3 study.

OD with a RD strategy for diminutive and small polyps during BCSP colonoscopy would offer substantial cost savings without adversly affecting surveillance interval concordance.

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Risk of post sphincterotomy bleeding with antiplatelet and anticoagulant use - A propensity-matched analysis of United States Collaborative Network.

Our database analysis shows that patients on AC and APT are indeed at a higher risk of post sphincterotomy bleeding, compared to matched controls. Appropriate drug cessation period or alternative biliary decompression modalities may be utilized in these patients.

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Safety and Feasibility of Same-Day Discharge After Endoscopic Submucosal Dissection: A Western Multicenter Prospective Cohort Study.

SDD after ESD can be safe and feasible. Invasive cancer, lesions in the upper GI tract, those associated with longer procedure or performed by low ESD volume endoscopists are more likely to be admitted post-procedurally. Risk stratification of patients for SDD after ESD should help optimize resource utilization and enhance ESD uptake in the West.

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Utilization Pattern of Prophylactic Measures for Prevention of Post-ERCP Pancreatitis: A National Survey Study.

Physicians with higher annual ERCP volume, teaching hospital based ERCP practices and who regularly perform pancreatic ERCP are more likely to use PPS. Therapeutic ERCP fellowship training and recent entry into practice were also associated with PPS utilization. Indomethacin use appears to be more frequent than PPS. Our findings suggest IND is supplanting PPS as the preferred method of PEP prophylaxis.

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Gut

Acetyltransferase from Akkermansia muciniphila blunts colorectal tumourigenesis by reprogramming tumour microenvironment.

Amuc_2172 reprogrammed tumour microenvironment by inducing HSP70 secretion and promoting CTL-related immune response in the process of tumourigenesis.

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Dose escalation randomised study of efmarodocokin alfa in healthy volunteers and patients with ulcerative colitis.

Efmarodocokin alfa had an adequate safety and pharmacokinetic profile in HVs and patients. Biomarker data confirmed IL-22R pathway activation in the colonic epithelium. Results support further investigation of this non-immunosuppressive potential inflammatory bowel disease therapeutic.

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IL-17A-producing CD8+ T cells promote PDAC via induction of inflammatory cancer-associated fibroblasts.

We identified Tc17 as a novel protumourigenic CD8 + T-cell subtype in PDAC, which accelerated tumour growth via IL-17RA-dependent stroma modification. We described a crosstalk between three cell types, Tc17, fibroblasts and tumour cells, promoting PDAC progression, which resulted in poor prognosis for patients.

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Liver stiffness thresholds to predict disease progression and clinical outcomes in bridging fibrosis and cirrhosis.

The LS thresholds identified in this study may be useful for risk stratification of NASH patients with advanced fibrosis.

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Hepatology

5S rRNA pseudogene transcripts are associated with interferon production and inflammatory responses in alcohol-associated hepatitis.

Increased expression and binding availability of RNA5SP transcripts was associated with hepatic IFN production and inflammation in sAH. These data identify RNA5SP transcripts as a potential target to mitigate inflammation and hepatocellular injury in AH.

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Epidermal growth factor receptor modulates hepatitis e virus entry in human hepatocytes -HEP-22-1113.

Taken together, our study provides novel insights into the life cycle of HEV and identified EGFR as a possible target for future anti-viral strategies against HEV.

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Examining the interim proposal for name change to steatotic liver disease in the US population.

The current analysis assessed the proposed changes based on discussions from the consensus meeting. Although the definitions are an interim analysis of discussions, steatotic liver disease respects the underlying liver etiology and reduces stigma while increasing awareness of FL among viral and alcohol-associated steatosis/steatohepatitis.

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Liver-restricted deletion of the biliary atresia candidate gene Pkd1l1 causes bile duct dysmorphogenesis and ciliopathy.

Bile duct ligation of the Pkd1l1-deficient mouse model mirrors several aspects of the intrahepatic pathophysiology of biliary atresia in humans including bile duct dysmorphogenesis, peribiliary fibroinflammation, hepatic arteriopathy, and ciliopathy. This first genetically linked model of biliary atresia, the Pkd1l1 LKO mouse, may allow researchers a means to develop a deeper understanding of the pathophysiology of this serious and perplexing disorder, including the opportunity to identify rational therapeutic targets.

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Plasma proteomic signature of fatty liver disease: the Rotterdam Study.

Among the general population, several inflammatory and cardiometabolic plasma proteins were associated with FLD and fibrosis. Particularly plasma levels of FGF-21, IL-18R1 and CES1 were largely dependent on the presence of FLD and fibrosis, and may therefore be important in their pathogenesis.

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Rngtt governs biliary-derived liver regeneration initiation by transcriptional regulation of mTORC1 and Dnmt1 in zebrafish.

Furthermore, rptor and dnmt1 mutants displayed the same liver regeneration defects as rngtt mutation. In conclusion, our results suggest Rngtt is a new factor that initiates BEC-derived liver regeneration.

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The outcome of boosting mitochondrial activity in alcoholic liver disease (ALD) is organ-dependent.

Improving mitochondrial respiration by liver-specific Mcj silencing might become a novel therapeutic approach for treating ALD.

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J Hepatol

A Human Liver Organoid Screening Platform for DILI Risk Prediction.

The high throughput and liver-on-chip system exhibit enhanced in vivo-like function and demonstrate the potential utility of these platforms for hepatotoxicity risk assessment. Tenofovir-inarigivr associated hepatotoxicity was observed and correlates with the clinical manifestation of DILI observed in patients.

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Utilization of livers donated after circulatory death for transplantation - An international comparison.

We highlight a significant number of discarded and consequently unused DCD liver offers. Countries with more routine use of in- and ex-situ machine perfusion strategies showed better DCD utilization rates without compromised outcome. Impact and implications A significant number of Maastricht type III DCD livers are discarded across Europe and North America today. The overall utilization rate among eight Western countries is 28.5%, but varies significantly between 18.9% and 74.2%. For example, the median DCD III liver utilization in five countries, e.g., Belgium, France, Italy, Switzerland, and Spain is 65%, in contrast to 24% in the Netherlands, UK and US. Despite this, and despite different rules and strategies for organ acceptance and preservation, the one and five-year graft survival remains currently relatively comparable among al participating countries. Factors which impact on DCD liver acceptance rates include the national pre-selections of donors, before the offer is made, as well as cutoffs for key risk factors, including donor age and donor warm ischemia time. In addition, a highly varying experience with modern machine perfusion technology is noticed. In situ and ex situ liver perfusion concepts, and assessment tools for type III DCD livers before transplantation may be one key part for the observed differences in better DCD III utilization.

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Neurogastroenterol Motil

Efficacy and safety of olorinab, a full agonist of the cannabinoid receptor 2, for the treatment of abdominal pain in patients with irritable bowel syndrome: Results from a phase 2b randomized placebo-controlled trial (CAPTIVATE).

Although olorinab was well-tolerated and improved weekly AAPS, the primary endpoint was not met. However, in participants with moderate-to-severe pain at baseline (AAPS =6.5), olorinab 50 mg significantly improved weekly AAPS compared with placebo. NCT04043455.

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Efficacy of aprepitant as a prophylactic medication in adults with cyclic vomiting syndrome.

Aprepitant is a safe and effective prophylactic medication in adults with refractory CVS. Adequate insurance coverage is a major barrier preventing its use.

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Electrophysiological and morphological features of myenteric neurons of human colon revealed by intracellular recording and dye fills.

Human enteric neurons share many features with laboratory animals, but the combinations of features in individual cells appear more variable.

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Gastrointestinal-Specific symptom anxiety in patients with gastroparesis: Relationships to symptom severity and quality of life.

The VSI is an adequate measure of GI-specific anxiety in patients with gastroparesis. Higher GI-specific anxiety was associated with increased patient-reported gastroparesis symptom severity and decreased quality of life, beyond depression/anxiety.

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The effect of combined oral contraceptives and Nexplanon on gastroesophageal reflux disease in premenopausal women: A nationwide database analysis.

Combined oral contraceptives is an independent risk factor for GERD, while Nexplanon has a limited protective effect. Further studies are needed to confirm the different effects on GERD of these two contraceptives.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Am J Gastroenterol

Application of the Latest Advances in Evidence-Based Medicine in Primary Biliary Cholangitis.

These include updates to prognostic models on risk stratification, new noninvasive tools for staging of disease, updates to the appropriate use of and long-term treatment results with obeticholic acid as a second-line treatment, the emerging therapeutic role of fibrates, and the advancement of investigational agents for managing PBC. In this updated expert consensus document, we provide updates on staging, the use of noninvasive prognostic tools, and a treatment algorithm to provide evidence-based and practical tools for clinicians who manage PBC, with the ultimate goal to improve the long-term outcomes for patients with this chronic liver disease.

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Gastroenterology

Drug Treatments for Gastroparesis - why is the cupboard so bare?

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Gut

Clinical advances: pregnancy in gastroenterologic and hepatic conditions.

To be able to provide the best possible care to these patients, gastroenterologists need to be aware of (and familiar with) the various nuances and caveats related to the care of pregnant patients who either have underlying gastrointestinal (GI) conditions or present with GI and liver disorders. Here, we offer a clinical update with references more recent than 2018, along with a few words about SARS-CoV-2 infection and its relevance to pregnancy.

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J Hepatol

Advanced endoscopy meets molecular diagnosis of cholangiocarcinoma.

This involves a multi-pronged approach incorporating advanced imaging, endoscopic methods, multiple approaches to tissue sampling and molecular markers. We also provide an algorithmic approach for the sequential use of these strategies.

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An adipocentric perspective on the development and progression of non-alcoholic fatty liver disease.

e. fat storage capacity and metabolic flexibility), promoting NAFL/NASH development and progression.

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Healthcare and socioeconomic costs of NAFLD: a global framework to navigate the uncertainties.

Lastly, we propose a global NAFLD/NASH investment framework to guide the development of achievable yet ambitious country-specific targets and strategic actions to optimise resource allocation and reduce the prevalence of NAFLD and NASH. Its focus on high-level inputs will be critical to enabling a political and financial environment that supports clinical-level implementation of NAFLD prevention, treatment and care efforts, across al settings.

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Nursing Care For Patients With Cirrhosis.

In the primary care setting, nurses should play an important role in the care of patients with compensated cirrhosis and also facilitate early diagnosis of cirrhosis in subjects at risk of liver diseases. This review calls for an improved global liver diseases education program for nurses and increased awareness among al healthcare providers and policy makers of the positive impacts of advanced or specialist nursing practice in this domain.

Pubmed   Journal   ReadQx 


Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol

"Open a can of worms": eosinophilic liver infiltration due to Clonorchis sinensis infection.

Pubmed   Journal   ReadQx 

Calendar of Courses, Symposiums and Conferences.

Pubmed   Journal   ReadQx 

Combined antero-retrograde endoscopic rendezvous approach for placing a colonic stent in a short bowel syndrome.

Pubmed   Journal   ReadQx 

De-escalate Don't Escalate: Essential Steps to Effectively Recognize and Manage the Patient Who Is Angry and Disruptive.

Pubmed   Journal   ReadQx 

Evaluation of Post-POEM GERD: Underestimate or Overestimate?

Pubmed   Journal   ReadQx 

Iatrogenic Portobiliary Fistula.

Pubmed   Journal   ReadQx 

Isolated Small Bowel Varices Diagnosed by Contrast-Enhanced Ultrasound.

Pubmed   Journal   ReadQx 

Low Risk of Lymphoma in Children With IBD Is Reassuring to Clinicians and Families.

Pubmed   Journal   ReadQx 

Odynophagia Secondary to Mpox-Associated Esophageal Ulceration.

Pubmed   Journal   ReadQx 

Persistent Gastrostomy Site Infection Due to Rib Fracture.

Pubmed   Journal   ReadQx 

Point-Counterpoint: Why Has Screening and Surveillance for Barrett's Esophagus Fallen Short in Stemming the Rising Incidence of Esophageal Adenocarcinoma?

Pubmed   Journal   ReadQx 

Racial and ethnic disparities in years of potential life loss among patients with cirrhosis during the COVID-19 pandemic in the United States.

Pubmed   Journal   ReadQx 

Reviewer Recognition.

Pubmed   Journal   ReadQx 

Screening for Lynch Syndrome: Optimal Strategies and Performance Remain a Moving Target.

Pubmed   Journal   ReadQx 

The American Journal of Gastroenterology: Reflections on 2022 and the Road Ahead.

Pubmed   Journal   ReadQx 

Clin Gastroenterol Hepatol

Biodegradable stenting in a patient with a refractory biliary stricture.

Pubmed   Journal   ReadQx 

Designing the Endoscopy Lab to Optimize Training.

Pubmed   Journal   ReadQx 

Endoscopic removal and typical presentation of biliary cast formation.

Pubmed   Journal   ReadQx 

EVALUATION OF TOFACITINIB IN PRIMARY SCLEROSING CHOLANGITIS AND ASSOCIATED COLITIS: A MULTICENTER, RETROSPECTIVE STUDY.

Pubmed   Journal   ReadQx 

Geographic Variation in NAFLD Prevalence and Subspecialty Care Utilization Among Insured Adults in the United States.

Pubmed   Journal   ReadQx 

Misdiagnosis of Gastroparesis is Common: A Retrospective Review of Patients Referred to a Tertiary Gastroenterology Practice.

Pubmed   Journal   ReadQx 

Physical activity intensity, genetic predisposition, and risk of non-alcoholic fatty liver disease: A prospective cohort study.

Pubmed   Journal   ReadQx 

Validation of The Model for End-Stage Liver Disease 3.0 in Korean Patients on the Liver Transplant Waiting List.

Pubmed   Journal   ReadQx 

Endoscopy

"Snare-pulley" clip-with-line technique to prevent polyp migration after endoscopic resection of a polyp in the third portion of the duodenum.

Pubmed   Journal   ReadQx 

Candy cane syndrome: a new endoscopic treatment for this underappreciated surgical complication.

Pubmed   Journal   ReadQx 

Creating and improving highly effective endoscopic teams.

Pubmed   Journal   ReadQx 

Efficacy of short-bending sphincterotome for difficult biliary cannulation in double-balloon enteroscopy-assisted ERCP.

Pubmed   Journal   ReadQx   PMC

Endoscopic hemostasis of spurting colonic diverticular bleeding using the combination of self-assembling peptide solution and endoscopic band ligation.

Pubmed   Journal   ReadQx 

Endoscopic intermuscular dissection of rectal T1 cancer with adaptive traction: use of additional loops to improve traction directly on the circular muscular layer.

Pubmed   Journal   ReadQx 

Endoscopic placement of a self-expandable metal stent for malignant small-intestine obstruction using a digital cholangioscope-guided approach.

Pubmed   Journal   ReadQx   PMC

Endoscopic removal of an appendiceal foreign body using a disposable pancreaticobiliary imaging catheter.

Pubmed   Journal   ReadQx   PMC

Endoscopic resection of a huge Vanek's tumor (inflammatory fibroid polyp).

Pubmed   Journal   ReadQx 

Endoscopic submucosal tunnel dissection with an elastic traction device for a circumferential superficial esophageal neoplasm.

Pubmed   Journal   ReadQx   PMC

Endoscopic transpapillary repositioning of a migrated cystic duct tube using a gooseneck snare technique.

Pubmed   Journal   ReadQx   PMC

Endoscopic vacuum therapy in a patient without nasal access.

Pubmed   Journal   ReadQx   PMC

Laparoscopic and endoscopic combined surgery to treat a large superficial nonampullary duodenal tumor.

Pubmed   Journal   ReadQx 

Linear array endoscopic ultrasonography for a patient with situs inversus totalis.

Pubmed   Journal   ReadQx 

Modified technique for deployment of a lumen-apposing metal stent during endoscopic ultrasound-guided choledochoduodenostomy in minimally dilated duct.

Pubmed   Journal   ReadQx 

Novel clip-traction band device-assisted endoscopic submucosal dissection for superficial pharyngeal carcinoma.

Pubmed   Journal   ReadQx 

Pretraction-assisted endoscopic submucosal dissection for the treatment of a rectal neuroendocrine tumor.

Pubmed   Journal   ReadQx   PMC

Radiation-free digital cholangioscopy-guided removal of bile duct foreign body and holmium laser lithotripsy for large common bile duct stones.

Pubmed   Journal   ReadQx 

Spigelman IV: can intensive cold snaring avoid duodenectomy in familial adenomatous polyposis?

Pubmed   Journal   ReadQx 

Successful omental patch for huge colonic perforation using regraspable clip.

Pubmed   Journal   ReadQx 

Successful retrieval of migrated and embedded fully covered self-expanding metal stent using "snare and lithotripter" technique.

Pubmed   Journal   ReadQx   PMC

The accidental discovery of pancreatic ductal adenocarcinoma on percutaneous cholangioscopy through a T-tube tract.

Pubmed   Journal   ReadQx   PMC

Three-arm endoscopic mucosal resection for gastric adenocarcinoma of fundic gland type.

Pubmed   Journal   ReadQx   PMC

Underwater clipping in the colon.

Pubmed   Journal   ReadQx 

Unique endoscopic and histological findings of early gastric cancer with surrounding map-like redness detected 10 years after successful Helicobacter pylori eradication.

Pubmed   Journal   ReadQx   PMC

Gastrointest Endosc

Artificial Intelligence-assisted Treatment Strategy for T1 Colorectal Cancer after Endoscopic Resection.

Pubmed   Journal   ReadQx 

COVID-19 Associated Colitis.

Pubmed   Journal   ReadQx   PMC

Hybrid Endoscopic Submucosal Dissection and Endoscopic Full-Thickness Resection for Complete Resection of a T2 Colorectal Adenocarcinoma in a Non-Surgical Candidate.

Pubmed   Journal   ReadQx 

Seminal gland metastases from gastric adenocarcinoma.

Pubmed   Journal   ReadQx 

Top Tips for balloon enteroscopy.

Pubmed   Journal   ReadQx 

Gut

Neuroactive changes in the bowel of patients with IBS on low FODMAP diet: another piece of the puzzle.

Pubmed   Journal   ReadQx 

Hepatology

April 2023 Hepatology Highlights.

Pubmed   Journal   ReadQx 

Hepatic steatosis provides the terroir that promotes the development of cardiovascular risk factors and disease.

Pubmed   Journal   ReadQx 

Hepatitis delta: epidemiology to recent advances in therapeutic agents.

Pubmed   Journal   ReadQx 

Letter to the Editor: Living donor liver transplantation for people with PSC.

Pubmed   Journal   ReadQx 

Liver resection for HCC in patients with metabolic syndrome: questions answered, questions raised.

Pubmed   Journal   ReadQx 


Letters&Replies

Letters to the editors and authors’ replies

Clin Gastroenterol Hepatol

Response to Letter to the Editor re.: ASSOCIATION OF CHRONIC PANCREATITIS PAIN FEATURES WITH PHYSICAL, MENTAL AND SOCIAL HEALTH.

Pubmed   Journal   ReadQx 

The Risk of Developing Long COVID in Patients with Inflammatory Bowel Diseases: Do Immunosuppressive Drugs Matter?

Pubmed   Journal   ReadQx 

Gastroenterology

LTE response: Serotonin in gastrointestinal disorders: delineating peripheral versus central effects.

Pubmed   Journal   ReadQx 

Not only pSM1 but intramucosal carcinoma should also be considered for ESD because pSM1 invasion is brutal to diagnose, even with magnification.

Pubmed   Journal   ReadQx 

Reply: application of administrative data towards epidemiological research.

Pubmed   Journal   ReadQx 

Gut

Considerations for peripheral blood transport and storage during large-scale multicentre metabolome research.

Pubmed   Journal   ReadQx 

In silico method to maximise the biological potential of understudied metabolomic biomarkers: a study in pre-eclampsia.

Pubmed   Journal   ReadQx 

J Hepatol

A risk prediction model for hepatocellular carcinoma after hepatitis B surface antigen seroclearance: has the correct patient cohort been targeted?

Pubmed   Journal   ReadQx 

Fairness Metrics: Additional Principles to Consider for Improving MELD.

Pubmed   Journal   ReadQx 

Response to Letter to the Editor Written by Binet.

Pubmed   Journal   ReadQx 

Survival Benefit Of Lymphadenectomy For Intrahepatic Cholangiocarcinoma: It Might Be Gold Even If It Does Not Glitter.

Pubmed   Journal   ReadQx